February 6, 2007
HOUSTON - The South Central VA Health Care Network has awarded a $100,000 pilot study research grant to David M. Green, M.D., staff physician in the Operative Care Line at the Michael E. DeBakey VA Medical Center (MEDVAMC).
The two-year grant will help fund Green's research to study how acute inflammatory leukocytes contribute to the destruction of mechanically traumatized cartilage with the goal of devising therapies that will block cartilage breakdown and chondrocyte death and prevent the development of osteoarthritis.
“Joint injury can lead to a post-traumatic arthritis in up to 55 percent of patients. With ongoing military activity, the Department of Veterans Affairs can anticipate an increasing number of young soldiers will receive injuries leading to post-traumatic osteoarthritis,” said Green. “Our current treatments of joint replacement or joint fusion and restriction of activity are not acceptable for young to middle-aged veterans. We need better insights into the factors that cause post-traumatic arthritis with the goal of developing interventions that can be applied immediately after injury.”
The overarching intent of the South Central VA Health Care Network Research Grants Program is to provide opportunities for junior VA research investigators. All applications were reviewed with respect to major strengths and weaknesses in areas such as the significance of the study proposed, scientific approach, and the adequacy of sampling plan, proposed protections of human subjects, and proposed budget.
Green, who is also an assistant professor of Orthopedic Surgery at Baylor College of Medicine, earned his medical degree from the University of Texas Medical School at Galveston and a Master of Science degree in biology from the University of Houston at Clear Lake. He completed an internship in general surgery, a residency in orthopedic surgery, and a fellowship in orthopedic research at Baylor College of Medicine. Green also completed a fellowship in orthopedic sports medicine at the Hospital for Special Surgery in New York.
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